TRAPPC10

Chr 21q22.3

trafficking protein particle complex subunit 10

Aliases:: EHOC-1, TRS130
MANE:: ENST00000291574.9

OMIM: 602103 ↗NCBI: 7109 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TRAPPC10 · P48553

v62025-08-01

Predicted Aligned Error matrix for TRAPPC10 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

79.0/ 100

Confident

1,259 residues

Confidence breakdown

Very high(≥ 90)34%
Confident(70–90)46%
Low(50–70)10%
Very low(< 50)11%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodevelopmental disorder with microcephaly, short stature, and speech delay
0.56
neurodegenerative disease
0.44
autosomal recessive primary microcephaly
0.38
Intellectual disability
0.26
ocular hypotension
0.14
Crohn disease
0.11
idiopathic generalized epilepsy
0.10
atrial septal defect
0.07
Meckel syndrome
0.07
Heterotaxia
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Trafficking protein particle complex subunit 10

Specific subunit of the TRAPP (transport protein particle) II complex, a highly conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether