TRAPPC4

Chr 11q23.3

trafficking protein particle complex subunit 4

Aliases:: TRS23, SBDN, PTD009
MANE:: ENST00000533632.6

OMIM: 610971 ↗NCBI: 51399 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TRAPPC4 · Q9Y296

v62025-08-01

Predicted Aligned Error matrix for TRAPPC4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

90.6/ 100

Very high

219 residues

Confidence breakdown

Very high(≥ 90)78%
Confident(70–90)17%
Low(50–70)3%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodevelopmental disorder with epilepsy, spasticity, and brain atrophy
0.70
Glycogen storage disease due to glucose-6-phosphatase deficiency
0.57
Glycogen storage disease due to glucose-6-phosphatase deficiency type b
0.57
congenital disorder of glycosylation, type IIw
0.53
glycogen storage disease I
0.46
disorder of glycogen metabolism
0.45
hereditary disease
0.41
complex neurodevelopmental disorder
0.37
neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies
0.34
congenital disorder of glycosylation
0.26

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Trafficking protein particle complex subunit 4

Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase (Probable). Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (PubMed:31794024). May play a role in dendrite postsynaptic membrane trafficking (By similarity)