TRDN

Chr 6q22.31

triadin

Aliases:: TRISK
MANE:: ENST00000334268.9

OMIM: 603283 ↗NCBI: 10345 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

TRDN · Q13061

v62025-08-01

Predicted Aligned Error matrix for TRDN — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

47.6/ 100

Very low

729 residues

Confidence breakdown

Very high(≥ 90)2%
Confident(70–90)7%
Low(50–70)20%
Very low(< 50)71%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Catecholaminergic polymorphic VT
BIALLELIC, autosomal or pseudoautosomal
Congenital myopathy
BIALLELIC, autosomal or pseudoautosomal
Long QT syndrome
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

catecholaminergic polymorphic ventricular tachycardia
0.73
catecholaminergic polymorphic ventricular tachycardia 1
0.57
Abnormality of the cardiovascular system
0.54
Prolonged QT interval
0.48
Abnormality of the skeletal system
0.38
familial long QT syndrome
0.38
Romano-Ward syndrome
0.37
amyotrophic lateral sclerosis
0.31
hypotensive disorder
0.29
nervous system disorder
0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Triadin

Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact (By similarity). Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats