TRHR

Chr 8q23.1

thyrotropin releasing hormone receptor

MANE:: ENST00000518632.2

OMIM: 188545 ↗NCBI: 7201 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TRHR · P34981

v62025-08-01

Predicted Aligned Error matrix for TRHR — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

79.6/ 100

Confident

398 residues

Confidence breakdown

Very high(≥ 90)56%
Confident(70–90)20%
Low(50–70)5%
Very low(< 50)19%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Congenital hypothyroidism
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability

Disease associations (Open Targets)

hypothyroidism, congenital, nongoitrous, 7
0.73
central nervous system disorder
0.46
sickle cell disease
0.36
hypertensive disorder
0.34
essential hypertension
0.33
cerebellar ataxia
0.33
smoking initiation
0.30
Abnormal pupillary function
0.29
Spinocerebellar tract degeneration
0.28
liver disorder
0.28

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Thyrotropin-releasing hormone receptor

Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway