TRIM2

Chr 4q31.3

tripartite motif containing 2

Aliases:: KIAA0517, RNF86, CMT2R
MANE:: ENST00000338700.10

OMIM: 614141 ↗NCBI: 23321 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TRIM2 · Q9C040

v62025-08-01

Predicted Aligned Error matrix for TRIM2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.6/ 100

Confident

744 residues

Confidence breakdown

Very high(≥ 90)54%
Confident(70–90)32%
Low(50–70)4%
Very low(< 50)9%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Hereditary neuropathy
BIALLELIC, autosomal or pseudoautosomal
Hereditary neuropathy or pain disorder
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Charcot-Marie-Tooth disease type 2R
0.70
thyrotoxic periodic paralysis
0.30
Tietze syndrome
0.27
Abnormality of the integument
0.26
cervical carcinoma
0.21
ovarian neoplasm
0.21
thrombophilia
0.20
cardiomyopathy
0.20
axonal neuropathy
0.12
nonpapillary renal cell carcinoma
0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tripartite motif-containing protein 2

UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity (PubMed:24068738)