AlphaFold predicted structure
TRIM37 · O94972
Mean pLDDT
63.7/ 100
Low
964 residues
Confidence breakdown
- Very high(≥ 90)37%
- Confident(70–90)9%
- Low(50–70)3%
- Very low(< 50)50%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
TRIM37
Chr 17q22tripartite motif containing 37
- Aliases:
- KIAA0898, POB1, TEF3
- MANE:
- ENST00000262294.12
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Childhood solid tumours
BIALLELIC, autosomal or pseudoautosomalClefting
BIALLELIC, autosomal or pseudoautosomalDDG2P
BIALLELIC, autosomal or pseudoautosomalEmbryonal tumour of possible germline origin
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalIUGR and IGF abnormalities
BIALLELIC, autosomal or pseudoautosomalLikely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomalMonogenic short stature
BIALLELIC, autosomal or pseudoautosomal
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Disease associations (Open Targets)
mulibrey nanism
0.83hereditary disease
0.47Joubert syndrome 1
0.37neurodegenerative disease
0.36musculoskeletal system disorder
0.32major depressive disorder
0.27information processing speed
0.27major salivary gland cancer
0.24type 2 diabetes mellitus
0.21atrial fibrillation
0.12
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
E3 ubiquitin-protein ligase TRIM37
E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome (PubMed:28724525). Has anti-HIV activity (PubMed:24317724)
Diseases associated with TRIM37
Curated MONDO disease pages that list TRIM37 among their top associated genes.