TRIM63

Chr 1p36.11

tripartite motif containing 63

Aliases:: MURF-1, IRF, SMRZ
MANE:: ENST00000374272.4

OMIM: 606131 ↗NCBI: 84676 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

TRIM63 · Q969Q1

v62025-08-01

Predicted Aligned Error matrix for TRIM63 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.8/ 100

Confident

353 residues

Confidence breakdown

Very high(≥ 90)57%
Confident(70–90)24%
Low(50–70)5%
Very low(< 50)13%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Hypertrophic cardiomyopathy
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

cardiomyopathy, familial hypertrophic, 31
0.62
hypertrophic cardiomyopathy
0.53
hereditary disease
0.47
Abnormality of the cardiovascular system
0.46
idiopathic cardiomyopathy
0.34
familial hypertrophic cardiomyopathy
0.17
type 2 diabetes mellitus
0.16
neoplasm
0.10
preeclampsia
0.09
spinal muscular atrophy, facioscapulohumeral type
0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

E3 ubiquitin-protein ligase TRIM63

E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells