TRIOBP

Chr 22q13.1

TRIO and F-actin binding protein

Aliases:: HRIHFB2122, KIAA1662, Tara, TAP68
MANE:: ENST00000644935.1

OMIM: 609761 ↗NCBI: 11078 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

TRIOBP · Q9H2D6

v62025-08-01

Predicted Aligned Error matrix for TRIOBP — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

40.2/ 100

Very low

2,365 residues

Confidence breakdown

Very high(≥ 90)9%
Confident(70–90)5%
Low(50–70)3%
Very low(< 50)83%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Monogenic hearing loss
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

hearing loss, autosomal recessive
0.73
hearing loss disorder
0.56
deafness
0.54
Rare genetic deafness
0.47
nonsyndromic genetic hearing loss
0.43
autosomal dominant nonsyndromic hearing loss
0.39
Hearing impairment
0.33
presbycusis
0.31
Alzheimer disease
0.28
neurodegenerative disease
0.28

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

TRIO and F-actin-binding protein

Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559)

Curated MONDO disease pages that list TRIOBP among their top associated genes.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with TRIOBP