AlphaFold predicted structure
TRIP11 · Q15643
Mean pLDDT
66.0/ 100
Low
1,979 residues
Confidence breakdown
- Very high(≥ 90)0%
- Confident(70–90)61%
- Low(50–70)17%
- Very low(< 50)22%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
TRIP11
Chr 14q32.12thyroid hormone receptor interactor 11
- Aliases:
- CEV14, Trip230, GMAP-210, GMAP210
- MANE:
- ENST00000267622.8
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalSkeletal dysplasia
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomalOsteogenesis imperfecta
Disease associations (Open Targets)
Achondrogenesis type 1A
0.79odontochondrodysplasia 1
0.75achondrogenesis type IA
0.64cancer
0.58achondrogenesis
0.47connective tissue disorder
0.46TRIP11-related skeletal dysplasia
0.44hereditary disease
0.42odontochondrodysplasia
0.38neurodegenerative disease
0.26
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Thyroid receptor-interacting protein 11
Is a membrane tether required for vesicle tethering to Golgi. Has an essential role in the maintenance of Golgi structure and function (PubMed:25473115, PubMed:30728324). It is required for efficient anterograde and retrograde trafficking in the early secretory pathway, functioning at both the ER-to-Golgi intermediate compartment (ERGIC) and Golgi complex (PubMed:25717001). Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription
Diseases associated with TRIP11
Curated MONDO disease pages that list TRIP11 among their top associated genes.