TRPC5

Chr Xq23

transient receptor potential cation channel subfamily C member 5

Aliases:: PPP1R159
MANE:: ENST00000262839.3

OMIM: 300334 ↗NCBI: 7224 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TRPC5 · Q9UL62

v62025-08-01

Predicted Aligned Error matrix for TRPC5 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.2/ 100

Confident

973 residues

Confidence breakdown

Very high(≥ 90)37%
Confident(70–90)32%
Low(50–70)6%
Very low(< 50)26%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Intellectual disability
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Severe early-onset obesity
X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)
DDG2P
X-LINKED: hemizygous mutation in males, biallelic mutations in females

Disease associations (Open Targets)

obesity due to melanocortin 4 receptor deficiency
0.21
obesity disorder
0.21
Obesity
0.21
Intellectual disability
0.12
breast carcinoma
0.10
breast cancer
0.10
colorectal carcinoma
0.10
autism
0.08
developmental and/or epileptic encephalopathy with spike-wave activation in sleep
0.08
Hypoglycemia
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Short transient receptor potential channel 5

Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:16284075, PubMed:38959890, PubMed:37137991). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity). Acts on distinct neuronal populations in the hypothalamus to regulate innate behaviors including feeding, anxiety (flight/fight/fear), socialization, and maternal care (By similarity)