TRPM7

Chr 15q21.2

transient receptor potential cation channel subfamily M member 7

Aliases:: CHAK1, LTRPC7, TRP-PLIK
MANE:: ENST00000646667.1

OMIM: 605692 ↗NCBI: 54822 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

TRPM7 · Q96QT4

v62025-08-01

Predicted Aligned Error matrix for TRPM7 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

69.5/ 100

Low

1,865 residues

Confidence breakdown

Very high(≥ 90)19%
Confident(70–90)45%
Low(50–70)11%
Very low(< 50)26%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Early onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Likely inborn error of metabolism
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Bleeding and platelet disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

amyotrophic lateral sclerosis-parkinsonism-dementia complex
0.43
intestinal hypomagnesemia 1
0.43
autosomal dominant macrothrombocytopenia
0.39
autoimmune disorder of central nervous system
0.31
Macrothrombocytopenia
0.19
macrothrombocytopenia, isolated
0.18
juvenile amyotrophic lateral sclerosis
0.13
ischemic stroke
0.11
central nervous system cancer
0.11
glioma
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Transient receptor potential cation channel subfamily M member 7

Bifunctional protein that combines an ion channel with an intrinsic kinase domain, enabling it to modulate cellular functions either by conducting ions through the pore or by phosphorylating downstream proteins via its kinase domain. The channel is highly permeable to divalent cations, specifically calcium (Ca2+), magnesium (Mg2+) and zinc (Zn2+) and mediates their influx (PubMed:11385574, PubMed:12887921, PubMed:15485879, PubMed:24316671, PubMed:35561741, PubMed:36027648). Controls a wide range of biological processes such as Ca2(+), Mg(2+) and Zn(2+) homeostasis, vesicular Zn(2+) release channel and intracellular Ca(2+) signaling, embryonic development, immune responses, cell motility, proliferation and differentiation (By similarity). The C-terminal alpha-kinase domain autophosphorylates cytoplasmic residues of TRPM7 (PubMed:18365021). In vivo, TRPM7 phosphorylates SMAD2, suggesting that TRPM7 kinase may play a role in activating SMAD signaling pathways. In vitro, TRPM7 kinase phosphorylates ANXA1 (annexin A1), myosin II isoforms and a variety of proteins with diverse cellular functions (PubMed:15485879, PubMed:18394644)