AlphaFold predicted structure
TTC12 · Q9H892
Mean pLDDT
90.3/ 100
Very high
705 residues
Confidence breakdown
- Very high(≥ 90)78%
- Confident(70–90)15%
- Low(50–70)3%
- Very low(< 50)4%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
TTC12
Chr 11q23.2tetratricopeptide repeat domain 12
- Aliases:
- FLJ13859, FLJ20535, TPARM
- MANE:
- ENST00000529221.6
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
BIALLELIC, autosomal or pseudoautosomalRespiratory ciliopathies including non-CF bronchiectasis
BIALLELIC, autosomal or pseudoautosomalPrimary ciliary disorders
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
ciliary dyskinesia, primary, 45
0.69Abnormal sperm morphology
0.46primary ciliary dyskinesia
0.46Reduced sperm motility
0.46hereditary disease
0.42depressive disorder
0.32mental disorder
0.31mood disorder
0.31major depressive disorder
0.30neurotic disorder
0.23
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Tetratricopeptide repeat protein 12
Cytoplasmic protein that plays a role in the proper assembly of dynein arm complexes in motile cilia in both respiratory cells and sperm flagella