TUBB4B

Chr 9q34.3

tubulin beta 4B class IVb

Aliases:: Beta2
MANE:: ENST00000340384.5

OMIM: 602660 ↗NCBI: 10383 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TUBB4B · P68371

v62025-08-01

Predicted Aligned Error matrix for TUBB4B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

92.3/ 100

Very high

445 residues

Confidence breakdown

Very high(≥ 90)83%
Confident(70–90)12%
Low(50–70)3%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Monogenic hearing loss
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Respiratory ciliopathies including non-CF bronchiectasis
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Retinal disorders
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

Leber congenital amaurosis with early-onset deafness
0.65
non-small cell lung carcinoma
0.62
breast cancer
0.61
breast carcinoma
0.60
neoplasm
0.60
prostate cancer
0.59
Hodgkins lymphoma
0.59
breast neoplasm
0.59
gout
0.59
plasma cell myeloma
0.58

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tubulin beta-4B chain

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin

Curated MONDO disease pages that list TUBB4B among their top associated genes.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with TUBB4B