TXNRD1

Chr 12q23.3

thioredoxin reductase 1

Aliases:: TXNR, GRIM-12, Trxr1, TXNR1
MANE:: ENST00000525566.6

OMIM: 601112 ↗NCBI: 7296 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

TXNRD1 · Q16881

Mean pLDDT

Not published

AlphaFold has not published a prediction for this sequence. This is common for very long proteins.

Confidence breakdown

Check AlphaFold DB

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

acute promyelocytic leukemia
0.59
neoplasm
0.40
brain cancer
0.37
acute myeloid leukemia
0.37
diphtheria
0.37
Arthritis
0.37
rheumatic disorder
0.37
myelodysplastic syndrome
0.33
non-small cell lung carcinoma
0.32
schizophrenia
0.31

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Thioredoxin reductase 1, cytoplasmic

Reduces disulfide protein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. A selenocysteine residue at the C-terminal active site is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437)