TYW1

Chr 7q11.21

tRNA-yW synthesizing protein 1 homolog

Aliases:: FLJ10900, MGC23001, MGC60291, YPL207W, TYW1A
MANE:: ENST00000359626.10

OMIM: 611243 ↗NCBI: 55253 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

TYW1 · Q9NV66

v62025-08-01

Predicted Aligned Error matrix for TYW1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.3/ 100

Confident

732 residues

Confidence breakdown

Very high(≥ 90)59%
Confident(70–90)18%
Low(50–70)5%
Very low(< 50)19%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Childhood onset hereditary spastic paraplegia
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Alzheimer disease
0.30
trauma complication
0.29
cerebral palsy
0.25
obesity disorder
0.25
malunion fracture
0.23
microcephaly
0.19
Intellectual disability
0.19
cardiomyopathy
0.18
poisoning
0.18
smoking initiation
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

Involved in the biosynthesis of wybutosine, a hyper modified guanosine with a tricyclic base located at position 37 of eukaryotic phenylalanine tRNA (tRNA(Phe)) that contributes to maintenance of the translational reading frame. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis