UBE2T

Chr 1q32.1

ubiquitin conjugating enzyme E2 T

Aliases:: HSPC150, FANCT
MANE:: ENST00000646651.1

OMIM: 610538 ↗NCBI: 29089 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

UBE2T · Q9NPD8

v62025-08-01

Predicted Aligned Error matrix for UBE2T — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

86.3/ 100

Confident

197 residues

Confidence breakdown

Very high(≥ 90)74%
Confident(70–90)4%
Low(50–70)12%
Very low(< 50)10%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Confirmed Fanconi anaemia or Bloom syndrome
BIALLELIC, autosomal or pseudoautosomal
COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Cytopenias and congenital anaemias
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Haematological malignancies cancer susceptibility
BIALLELIC, autosomal or pseudoautosomal
Haematological malignancies for rare disease
BIALLELIC, autosomal or pseudoautosomal
Limb disorders
BIALLELIC, autosomal or pseudoautosomal

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Disease associations (Open Targets)

Fanconi anemia
0.79
myelodysplastic syndrome
0.48
acute myeloid leukemia
0.46
hepatocellular carcinoma
0.12
breast carcinoma
0.11
neoplasm
0.11
breast cancer
0.11
glioblastoma
0.10
gastric cancer
0.10
non-small cell lung carcinoma
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Ubiquitin-conjugating enzyme E2 T

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784, PubMed:28437106). Also mediates monoubiquitination of FANCL and FANCI (PubMed:16916645, PubMed:17938197, PubMed:19111657, PubMed:19589784). May contribute to ubiquitination and degradation of BRCA1 (PubMed:19887602). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:20061386)