UNC45B

Chr 17q12

unc-45 myosin chaperone B

Aliases:: UNC45
MANE:: ENST00000394570.7

OMIM: 611220 ↗NCBI: 146862 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

UNC45B · Q8IWX7

v62025-08-01

Predicted Aligned Error matrix for UNC45B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

88.3/ 100

Confident

931 residues

Confidence breakdown

Very high(≥ 90)60%
Confident(70–90)33%
Low(50–70)6%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Congenital myopathy
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

myofibrillar myopathy 11
0.71
cataract 43
0.55
cataract
0.37
early-onset nuclear cataract
0.37
myopathy
0.33
dilated cardiomyopathy 1A
0.32
hereditary disease
0.19
kidney disorder
0.16
oral cavity neoplasm
0.06
neoplasm
0.04

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein unc-45 homolog B

Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development