AlphaFold predicted structure
UQCC3 · Q6UW78
Mean pLDDT
73.9/ 100
Confident
93 residues
Confidence breakdown
- Very high(≥ 90)14%
- Confident(70–90)51%
- Low(50–70)28%
- Very low(< 50)8%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
UQCC3
Chr 11q12.3ubiquinol-cytochrome c reductase complex assembly factor 3
- Aliases:
- UNQ655
- MANE:
- ENST00000377953.4
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Likely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomalMitochondrial disorder with complex III deficiency
BIALLELIC, autosomal or pseudoautosomalMitochondrial disorders
BIALLELIC, autosomal or pseudoautosomalPossible mitochondrial disorder - nuclear genes
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
Isolated CoQ-cytochrome C reductase deficiency
0.52mitochondrial complex III deficiency
0.43Abnormality of the skeletal system
0.13smoking initiation
0.09neoplasm
0.08viral infectious disease
0.07irritable bowel syndrome
0.06Alkuraya-Kucinskas syndrome
0.03esophageal disorder
0.03hepatocellular carcinoma
0.02
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Ubiquinol-cytochrome-c reductase complex assembly factor 3
Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology