AlphaFold predicted structure
UQCRB · P14927
Mean pLDDT
93.1/ 100
Very high
111 residues
Confidence breakdown
- Very high(≥ 90)86%
- Confident(70–90)8%
- Low(50–70)6%
- Very low(< 50)0%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
UQCRB
Chr 8q22.1ubiquinol-cytochrome c reductase binding protein
- Aliases:
- QP-C, QCR7, UQCR6
- MANE:
- ENST00000287022.10
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
BIALLELIC, autosomal or pseudoautosomalLikely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomalMitochondrial disorder with complex III deficiency
BIALLELIC, autosomal or pseudoautosomalMitochondrial disorders
BIALLELIC, autosomal or pseudoautosomalPossible mitochondrial disorder - nuclear genes
BIALLELIC, autosomal or pseudoautosomalUndiagnosed metabolic disorders
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalChildhood onset dystonia, chorea or related movement disorder
+2 more panels — install the extension to see the full list inline on any page.
Disease associations (Open Targets)
Isolated CoQ-cytochrome C reductase deficiency
0.72neurodegenerative disease
0.57mitochondrial complex III deficiency
0.50Alzheimer disease
0.39Parkinson disease
0.39lysosomal storage disease
0.39multiple sclerosis
0.39early-onset non-syndromic cataract
0.10Posterior polar cataract
0.09Total congenital cataract
0.09
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Cytochrome b-c1 complex subunit 7
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c