VCAN

Chr 5q14.2-q14.3

versican

Aliases:: PG-M
MANE:: ENST00000265077.8

OMIM: 118661 ↗NCBI: 1462 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

VCAN · P13611-2isoform

No predicted structure exists for the canonical P13611 sequence; metrics below describe this isoform.

v62025-08-01

Predicted Aligned Error matrix for VCAN — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

42.5/ 100

Very low

2,409 residues

Confidence breakdown

Very high(≥ 90)12%
Confident(70–90)11%
Low(50–70)2%
Very low(< 50)75%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Retinal disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Stickler syndrome
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Glaucoma (developmental)
Structural eye disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

Wagner disease
0.75
Abnormality of the skeletal system
0.57
diverticular disease
0.51
Retinal dystrophy
0.45
hereditary disease
0.42
eye disorder
0.37
abdominal aortic aneurysm
0.36
aortic aneurysm
0.36
carpal tunnel syndrome
0.36
Stickler syndrome
0.34

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Versican core protein

May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid