VEGFC

Chr 4q34.3

vascular endothelial growth factor C

Aliases:: VRP, VEGF-C
MANE:: ENST00000618562.2

OMIM: 601528 ↗NCBI: 7424 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

VEGFC · P49767

v62025-08-01

Predicted Aligned Error matrix for VEGFC — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.2/ 100

Confident

419 residues

Confidence breakdown

Very high(≥ 90)22%
Confident(70–90)46%
Low(50–70)12%
Very low(< 50)20%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Primary lymphoedema
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

Milroy disease
0.62
hypothyroidism
0.53
Abnormality of the skeletal system
0.48
thyroid gland disorder
0.41
neurodegenerative disease
0.37
diabetic macular edema
0.34
Alzheimer disease
0.33
macular retinal edema
0.33
retinal vein occlusion
0.32
choroidal neovascularization
0.28

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Vascular endothelial growth factor C

Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors