AlphaFold predicted structure
VIM · P08670
Mean pLDDT
77.1/ 100
Confident
466 residues
Confidence breakdown
- Very high(≥ 90)50%
- Confident(70–90)20%
- Low(50–70)6%
- Very low(< 50)24%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
VIM
Chr 10p13vimentin
- MANE:
- ENST00000544301.7
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Bilateral congenital or childhood onset cataracts
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownPaediatric disorders - additional genes
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownSevere insulin resistance and lipodystrophy syndromes
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownStructural eye disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
dengue disease
0.51early-onset non-syndromic cataract
0.46Partial congenital cataract
0.46Developmental cataract
0.43cataract
0.37pulverulent cataract
0.37Paralysis
0.25hypertensive disorder
0.19glioma
0.12neoplasm
0.12
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Vimentin
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (By similarity)
Diseases associated with VIM
Curated MONDO disease pages that list VIM among their top associated genes.