AlphaFold predicted structure
VPS45 · Q9NRW7
Mean pLDDT
90.6/ 100
Very high
570 residues
Confidence breakdown
- Very high(≥ 90)78%
- Confident(70–90)14%
- Low(50–70)3%
- Very low(< 50)5%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
VPS45
Chr 1q21.2vacuolar protein sorting 45 homolog
- Aliases:
- h-vps45, H1
- MANE:
- ENST00000644510.2
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalCytopenia - NOT Fanconi anaemia
BIALLELIC, autosomal or pseudoautosomalCytopenias and congenital anaemias
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
congenital neutropenia-myelofibrosis-nephromegaly syndrome
0.78Recurrent infections-myelofibrosis-nephromegaly syndrome
0.74severe congenital neutropenia
0.55neurodegenerative disease
0.46COVID-19
0.37hereditary disease
0.19mathematical ability
0.14schizophrenia
0.11deep vein thrombosis
0.09hepatocellular carcinoma
0.09
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Vacuolar protein sorting-associated protein 45
May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network