WBP2

Chr 17q25.1

WW domain binding protein 2

Aliases:: WBP-2, GRAMD6
MANE:: ENST00000254806.8

OMIM: 606962 ↗NCBI: 23558 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

WBP2 · Q969T9

v62025-08-01

Predicted Aligned Error matrix for WBP2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

72.2/ 100

Confident

261 residues

Confidence breakdown

Very high(≥ 90)41%
Confident(70–90)12%
Low(50–70)22%
Very low(< 50)26%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Monogenic hearing loss
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

hearing loss, autosomal recessive
0.47
deafness
0.35
psoriasis
0.21
Hypercholesterolemia
0.19
hyperlipidemia
0.15
morbid obesity
0.15
response to statin
0.15
metabolic disease
0.15
coronary artery disorder
0.13
breast cancer
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

WW domain-binding protein 2

Acts as a transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation (PubMed:16772533). In presence of estrogen, binds to ESR1-responsive promoters (PubMed:16772533). Synergizes with YAP1 to enhance PGR activity (PubMed:16772533). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR (By similarity)