WDHD1

Chr 14q22.2-q22.3

WD repeat and HMG-box DNA binding protein 1

Aliases:: AND-1, CTF4, CHTF4
MANE:: ENST00000360586.8

OMIM: 608126 ↗NCBI: 11169 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

WDHD1 · O75717

v62025-08-01

Predicted Aligned Error matrix for WDHD1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

74.5/ 100

Confident

1,129 residues

Confidence breakdown

Very high(≥ 90)55%
Confident(70–90)12%
Low(50–70)2%
Very low(< 50)31%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Paediatric disorders - additional genes
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Alzheimer disease
0.46
neurodegenerative disease
0.46
multiple sclerosis
0.46
lysosomal storage disease
0.46
Parkinson disease
0.46
Abnormality of limbs
0.27
microcephalic osteodysplastic primordial dwarfism
0.25
microcephalic osteodysplastic primordial dwarfism type II
0.25
fetal growth restriction
0.18
arthropathy
0.15

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

WD repeat and HMG-box DNA-binding protein 1

Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork