WDR19

Chr 4p14

WD repeat domain 19

Aliases:: Pwdmp, KIAA1638, FLJ23127, ORF26, DYF-2
MANE:: ENST00000399820.8

OMIM: 608151 ↗NCBI: 57728 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

WDR19 · Q8NEZ3

v62025-08-01

Predicted Aligned Error matrix for WDR19 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

86.3/ 100

Confident

1,342 residues

Confidence breakdown

Very high(≥ 90)39%
Confident(70–90)56%
Low(50–70)4%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Cystic kidney disease
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Ophthalmological ciliopathies
BIALLELIC, autosomal or pseudoautosomal
Rare multisystem ciliopathy disorders
BIALLELIC, autosomal or pseudoautosomal
Renal ciliopathies
BIALLELIC, autosomal or pseudoautosomal
Retinal disorders
BIALLELIC, autosomal or pseudoautosomal
Skeletal ciliopathies
BIALLELIC, autosomal or pseudoautosomal

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Disease associations (Open Targets)

Senior-Loken syndrome
0.80
cranioectodermal dysplasia
0.79
nephronophthisis
0.77
Jeune syndrome
0.74
asphyxiating thoracic dystrophy 5
0.74
Senior-Loken syndrome 8
0.70
spermatogenic failure 72
0.61
Retinal dystrophy
0.46
connective tissue disorder
0.45
short-rib thoracic dysplasia 9 with or without polydactyly
0.43

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

WD repeat-containing protein 19

As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in cilia function and/or assembly (PubMed:20889716, PubMed:36775821). Essential for functional IFT-A assembly and ciliary entry of GPCRs (PubMed:20889716, PubMed:36775821). Associates with the BBSome complex to mediate ciliary transport (By similarity)

Curated MONDO disease pages that list WDR19 among their top associated genes.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with WDR19