WDR62

Chr 19q13.12

WD repeat domain 62

Aliases:: DKFZP434J046, FLJ33298
MANE:: ENST00000401500.7

OMIM: 613583 ↗NCBI: 284403 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

WDR62 · O43379

v62025-08-01

Predicted Aligned Error matrix for WDR62 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

60.4/ 100

Low

1,518 residues

Confidence breakdown

Very high(≥ 90)34%
Confident(70–90)11%
Low(50–70)5%
Very low(< 50)50%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Malformations of cortical development
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal
Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Cerebral vascular malformations

Disease associations (Open Targets)

autosomal recessive primary microcephaly
0.81
hereditary disease
0.49
Intellectual disability
0.46
Skraban-Deardorff syndrome
0.36
Abnormality of the nervous system
0.34
Abnormality of neuronal migration
0.33
Abnormal cerebral morphology
0.32
atrial fibrillation
0.25
membranous glomerulonephritis
0.18
microcephaly 1, primary, autosomal recessive
0.13

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

WD repeat-containing protein 62

Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806)