WFDC2

Chr 20q13.12

WAP four-disulfide core domain 2

Aliases:: HE4, WAP5, dJ461P17.6, EDDM4
MANE:: ENST00000372676.8

OMIM: 617548 ↗NCBI: 10406 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

WFDC2 · Q14508

v62025-08-01

Predicted Aligned Error matrix for WFDC2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.1/ 100

Confident

124 residues

Confidence breakdown

Very high(≥ 90)47%
Confident(70–90)27%
Low(50–70)25%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Respiratory ciliopathies including non-CF bronchiectasis
BIALLELIC, autosomal or pseudoautosomal
Primary ciliary disorders
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

bronchiectasis and nasal polyposis
0.37
ovarian carcinoma
0.13
lung carcinoma
0.12
lung cancer
0.12
idiopathic pulmonary fibrosis
0.12
ovarian cancer
0.12
interstitial lung disease
0.11
endometrial cancer
0.11
chronic kidney disease
0.11
neoplasm
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

WAP four-disulfide core domain protein 2

Plays a critical role in lung development (By similarity). Required for terminal differentiation of bronchiole club cells (By similarity). Required for development of airway barrier mechanisms, such as lamellar body formation in type II alveolar epithelial cells and cilia formation on ciliated epithelial cells following initiation of respiration at birth (By similarity). Required for type I alveolar epithelial cell and vascular endothelial development in the lungs, thereby mediating blood-air barrier exchange (By similarity)