WIPF1

Chr 2q31.1

WAS/WASL interacting protein family member 1

Aliases:: WIP
MANE:: ENST00000679041.1

OMIM: 602357 ↗NCBI: 7456 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

WIPF1 · O43516

v62025-08-01

Predicted Aligned Error matrix for WIPF1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

58.5/ 100

Low

503 residues

Confidence breakdown

Very high(≥ 90)3%
Confident(70–90)21%
Low(50–70)35%
Very low(< 50)41%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Cytopenia - NOT Fanconi anaemia
BIALLELIC, autosomal or pseudoautosomal
Cytopenias and congenital anaemias
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Wiskott-Aldrich syndrome
0.66
atrial fibrillation
0.49
Abnormality of the skeletal system
0.42
atrial flutter
0.38
Increased blood pressure
0.31
osteonecrosis
0.29
hypertensive disorder
0.26
chronic obstructive pulmonary disease
0.26
cardiac arrhythmia
0.26
cardiovascular disorder
0.25

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

WAS/WASL-interacting protein family member 1

Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles (By similarity). Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus