WIPI2

Chr 7p22.1

WD repeat domain, phosphoinositide interacting 2

Aliases:: ATG21, CGI-50, FLJ12979, FLJ14217, FLJ42984
MANE:: ENST00000288828.9

OMIM: 609225 ↗NCBI: 26100 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

WIPI2 · Q9Y4P8

v62025-08-01

Predicted Aligned Error matrix for WIPI2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

76.0/ 100

Confident

454 residues

Confidence breakdown

Very high(≥ 90)60%
Confident(70–90)7%
Low(50–70)7%
Very low(< 50)27%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

intellectual developmental disorder with short stature and variable skeletal anomalies
0.63
neurodegenerative disease
0.54
autosomal recessive non-syndromic intellectual disability
0.46
smoking initiation
0.38
lysosomal storage disease
0.37
breast carcinoma
0.34
post term pregnancy
0.22
retinitis pigmentosa
0.11
Progressive cone dystrophy
0.10
facial nerve disorder
0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

WD repeat domain phosphoinositide-interacting protein 2

Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation (PubMed:20505359, PubMed:28561066). Involved in an early step of the formation of preautophagosomal structures (PubMed:20505359, PubMed:28561066). Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases (PubMed:28561066). Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P (PubMed:28890335). Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane (PubMed:20505359, PubMed:28561066)