WLS

Chr 1p31.3

Wnt ligand secretion mediator

Aliases:: FLJ23091, MRP, EVI, mig-14
MANE:: ENST00000262348.9

OMIM: 611514 ↗NCBI: 79971 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

WLS · Q5T9L3

v62025-08-01

Predicted Aligned Error matrix for WLS — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.6/ 100

Confident

541 residues

Confidence breakdown

Very high(≥ 90)46%
Confident(70–90)39%
Low(50–70)5%
Very low(< 50)9%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal
Structural eye disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Zaki syndrome
0.73
osteoporosis
0.44
bone disorder
0.43
open-angle glaucoma
0.32
total hip arthroplasty
0.30
osteoarthritis, hip
0.30
Abnormality of the gastrointestinal tract
0.29
glaucoma
0.28
urolithiasis
0.21
alcohol drinking
0.21

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein wntless homolog

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins (PubMed:34587386). Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity)