WNT10B

Chr 12q13.12

Wnt family member 10B

Aliases:: WNT-12, SHFM6
MANE:: ENST00000301061.9

OMIM: 601906 ↗NCBI: 7480 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

WNT10B · O00744

v62025-08-01

Predicted Aligned Error matrix for WNT10B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.1/ 100

Confident

389 residues

Confidence breakdown

Very high(≥ 90)53%
Confident(70–90)20%
Low(50–70)15%
Very low(< 50)12%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Limb disorders
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Split hand-split foot malformation
0.77
tooth agenesis
0.50
split hand-foot malformation
0.46
Oligodontia
0.37
split hand or/and split foot malformation
0.37
hereditary disease
0.19
hepatocellular carcinoma
0.10
neoplasm
0.08
central nervous system cancer
0.08
gastric cancer
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein Wnt-10b

Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin