WNT11

Chr 11q13.5

Wnt family member 11

MANE:: ENST00000322563.8

OMIM: 603699 ↗NCBI: 7481 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

WNT11 · O96014

v62025-08-01

Predicted Aligned Error matrix for WNT11 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

90.2/ 100

Very high

354 residues

Confidence breakdown

Very high(≥ 90)79%
Confident(70–90)14%
Low(50–70)2%
Very low(< 50)6%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Osteogenesis imperfecta
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

osteoporosis
0.37
osteoarthritis
0.37
Recurrent fractures
0.37
neurodegenerative disease
0.28
glomerulonephritis
0.28
male reproductive organ cancer
0.27
cardiomyopathy
0.22
rectosigmoid junction neoplasm
0.22
placenta praevia
0.21
Alzheimer disease
0.21

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein Wnt-11

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters