WNT2B

Chr 1p13.2

Wnt family member 2B

Aliases:: XWNT2
MANE:: ENST00000369684.5

OMIM: 601968 ↗NCBI: 7482 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

WNT2B · Q93097

v62025-08-01

Predicted Aligned Error matrix for WNT2B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

86.3/ 100

Confident

391 residues

Confidence breakdown

Very high(≥ 90)68%
Confident(70–90)16%
Low(50–70)7%
Very low(< 50)8%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Intestinal failure or congenital diarrhoea
BIALLELIC, autosomal or pseudoautosomal
Structural eye disease
BIALLELIC, autosomal or pseudoautosomal
Differences in sex development
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Diarrhea, Infantile
0.65
hypertensive disorder
0.49
essential hypertension
0.45
cardiovascular disorder
0.41
Increased blood pressure
0.41
stroke disorder
0.37
atrial fibrillation
0.36
Impaired feeding ability
0.33
Failure to thrive in infancy
0.33
Failure to thrive
0.33

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein Wnt-2b

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development