WNT3

Chr 17q21.31-q21.32

Wnt family member 3

Aliases:: MGC131950, MGC138321, MGC138323
MANE:: ENST00000225512.6

OMIM: 165330 ↗NCBI: 7473 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

WNT3 · P56703

v62025-08-01

Predicted Aligned Error matrix for WNT3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

88.3/ 100

Confident

355 residues

Confidence breakdown

Very high(≥ 90)70%
Confident(70–90)19%
Low(50–70)6%
Very low(< 50)5%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Hydrocephalus
BIALLELIC, autosomal or pseudoautosomal
Clefting
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Structural eye disease
BIALLELIC, autosomal or pseudoautosomal
VACTERL-like phenotypes

Disease associations (Open Targets)

neurodegenerative disease
0.53
tetra-amelia
0.51
Tetraamelia - multiple malformations
0.50
tetraamelia-multiple malformations syndrome
0.37
alcohol drinking
0.36
atrial fibrillation
0.36
Snoring
0.35
Abnormality of the skeletal system
0.33
Parkinson disease
0.32
hypertensive disorder
0.31

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Proto-oncogene Wnt-3

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:26902720). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity). Required for normal embryonic development, and especially for limb development (PubMed:14872406)