WNT4

Chr 1p36.12

Wnt family member 4

Aliases:: WNT-4
MANE:: ENST00000290167.11

OMIM: 603490 ↗NCBI: 54361 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

WNT4 · P56705

v62025-08-01

Predicted Aligned Error matrix for WNT4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

91.1/ 100

Very high

351 residues

Confidence breakdown

Very high(≥ 90)80%
Confident(70–90)12%
Low(50–70)5%
Very low(< 50)3%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Fetal anomalies
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Intellectual disability
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

mullerian aplasia and hyperandrogenism
0.71
SERKAL syndrome
0.66
Mayer-Rokitansky-Küster-Hauser syndrome
0.47
uterine corpus leiomyoma
0.44
endometriosis
0.41
Abnormality of the skeletal system
0.39
Mayer-Rokitansky-Küster-Hauser syndrome type 2
0.38
MURCS association
0.38
pelvic organ prolapse
0.37
colorectal cancer
0.35

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein Wnt-4

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung (PubMed:15317892, PubMed:16959810, PubMed:18179883, PubMed:18182450). Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development (By similarity). Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary (PubMed:15317892, PubMed:16959810, PubMed:18182450). Required for normal lung development and for normal patterning of trachael cartilage rings (By similarity)