WNT5A

Chr 3p14.3

Wnt family member 5A

Aliases:: hWNT5A
MANE:: ENST00000264634.9

OMIM: 164975 ↗NCBI: 7474 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

WNT5A · P41221

v62025-08-01

Predicted Aligned Error matrix for WNT5A — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

87.7/ 100

Confident

380 residues

Confidence breakdown

Very high(≥ 90)76%
Confident(70–90)10%
Low(50–70)6%
Very low(< 50)9%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Clefting
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Limb disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Skeletal dysplasia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
CAKUT
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Osteogenesis imperfecta

Disease associations (Open Targets)

Robinow syndrome
0.71
autosomal dominant Robinow syndrome
0.70
nephrolithiasis
0.37
gram-negative bacterial infections
0.32
Hernia
0.32
liver disorder
0.32
glomerulonephritis
0.28
brain cancer
0.27
leukoencephalopathy, motor delay, spasticity, and dysarthria syndrome
0.27
ureterolithiasis
0.26

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein Wnt-5a

Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity)