WNT7B

Chr 22q13.31

Wnt family member 7B

MANE:: ENST00000339464.9

OMIM: 601967 ↗NCBI: 7477 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

WNT7B · P56706

v62025-08-01

Predicted Aligned Error matrix for WNT7B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

90.6/ 100

Very high

349 residues

Confidence breakdown

Very high(≥ 90)71%
Confident(70–90)26%
Low(50–70)4%
Very low(< 50)0%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Matthew-Wood syndrome
0.59
Dupuytren Contracture
0.48
palmar fibromatosis
0.47
fasciitis
0.46
myopia
0.44
anophthalmia-microphthalmia syndrome
0.44
frozen shoulder
0.43
glaucoma
0.43
fibroblastic disorder
0.42
open-angle glaucoma
0.39

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein Wnt-7b

Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:30026314). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:30026314)