WNT9B

Chr 17q21.32

Wnt family member 9B

Aliases:: WNT14B
MANE:: ENST00000290015.7

OMIM: 602864 ↗NCBI: 7484 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

WNT9B · O14905

v62025-08-01

Predicted Aligned Error matrix for WNT9B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

83.6/ 100

Confident

357 residues

Confidence breakdown

Very high(≥ 90)59%
Confident(70–90)20%
Low(50–70)12%
Very low(< 50)9%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Paediatric disorders - additional genes
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

glaucoma
0.40
Varicose veins
0.40
hypertensive disorder
0.39
essential hypertension
0.38
bilateral renal agenesis
0.38
chronic kidney disease
0.33
lymphatic system disorder
0.30
vein disorder
0.30
open-angle glaucoma
0.29
coronary atherosclerosis
0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein Wnt-9b

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Plays a role in cranofacial development and is required for normal fusion of the palate during embryonic development (By similarity)