WSB2

Chr 12q24.23

WD repeat and SOCS box containing 2

Aliases:: SBA2, MGC10210
MANE:: ENST00000315436.8

NCBI: 55884 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

WSB2 · Q9NYS7

v62025-08-01

Predicted Aligned Error matrix for WSB2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.9/ 100

Confident

404 residues

Confidence breakdown

Very high(≥ 90)68%
Confident(70–90)14%
Low(50–70)6%
Very low(< 50)12%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Ataxia and cerebellar anomalies - narrow panel
BIALLELIC, autosomal or pseudoautosomal
Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.50
neurodevelopmental disorder
0.45
prostate carcinoma
0.32
muscular disease
0.25
hepatocellular carcinoma
0.08
cancer
0.08
lung carcinoma
0.08
lung cancer
0.08
breast carcinoma
0.06
breast cancer
0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

WD repeat and SOCS box-containing protein 2

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins