YIF1B

Chr 19q13.2

Yip1 interacting factor homolog B, membrane trafficking protein

Aliases:: FinGER8
MANE:: ENST00000339413.11

OMIM: 619109 ↗NCBI: 90522 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

YIF1B · Q5BJH7

v62025-08-01

Predicted Aligned Error matrix for YIF1B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.3/ 100

Confident

314 residues

Confidence breakdown

Very high(≥ 90)38%
Confident(70–90)26%
Low(50–70)14%
Very low(< 50)23%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Childhood onset dystonia, chorea or related movement disorder
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Kaya-Barakat-Masson syndrome
0.74
hereditary disease
0.41
cancer
0.08
neoplasm
0.06
hepatocellular carcinoma
0.05
diabetic ketoacidosis
0.02
Abnormality of the skeletal system
0.02
myxosarcoma
0.02
cutaneous melanoma
0.01
lung carcinoma
0.01

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein YIF1B

Functions in endoplasmic reticulum to Golgi vesicle-mediated transport and regulates the proper organization of the endoplasmic reticulum and the Golgi (By similarity). Plays a key role in targeting to neuronal dendrites receptors such as HTR1A (By similarity). Plays also a role in primary cilium and sperm flagellum assembly probably through protein transport to these compartments (PubMed:33103737)