YY1AP1

Chr 1q22

YY1 associated protein 1

Aliases:: YY1AP, HCCA2, YAP
MANE:: ENST00000355499.9

OMIM: 607860 ↗NCBI: 55249 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

YY1AP1 · Q9H869

v62025-08-01

Predicted Aligned Error matrix for YY1AP1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

53.7/ 100

Low

796 residues

Confidence breakdown

Very high(≥ 90)14%
Confident(70–90)17%
Low(50–70)7%
Very low(< 50)62%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Cerebral vascular malformations
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

grange syndrome
0.73
neurodegenerative disease
0.23
hereditary disease
0.19
atrial fibrillation
0.09
hepatocellular carcinoma
0.09
neoplasm
0.08
cancer
0.08
psoriasis
0.04
mathematical ability
0.04
kidney failure
0.03

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

YY1-associated protein 1

Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication (PubMed:27939641). Enhances transcription activation by YY1 (PubMed:14744866). Plays a role in cell cycle regulation (PubMed:17541814, PubMed:27939641)