AlphaFold predicted structure
ZBTB20 · Q9HC78
Mean pLDDT
52.2/ 100
Low
741 residues
Confidence breakdown
- Very high(≥ 90)1%
- Confident(70–90)31%
- Low(50–70)7%
- Very low(< 50)61%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
ZBTB20
Chr 3q13.31zinc finger and BTB domain containing 20
- Aliases:
- ODA-8S, DKFZp566F123, DPZF
- MANE:
- ENST00000675478.1
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFamilial diabetes
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownHydrocephalus
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownIntellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedMonogenic diabetes
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedMonogenic hearing loss
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedSkeletal dysplasia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
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Disease associations (Open Targets)
Primrose syndrome
0.81Intellectual disability - cataracts - calcified pinnae - myopathy
0.70hereditary disease
0.53Intellectual disability
0.50diabetes mellitus
0.43type 2 diabetes mellitus
0.41prostate carcinoma
0.40skin aging
0.39androgenetic alopecia
0.37neurodevelopmental disorder
0.35
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Zinc finger and BTB domain-containing protein 20
May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (PubMed:11352661). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity)
Diseases associated with ZBTB20
Curated MONDO disease pages that list ZBTB20 among their top associated genes.