AlphaFold predicted structure
ZEB1 · P37275
Mean pLDDT
47.9/ 100
Very low
1,124 residues
Confidence breakdown
- Very high(≥ 90)1%
- Confident(70–90)19%
- Low(50–70)7%
- Very low(< 50)73%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
ZEB1
Chr 10p11.22zinc finger E-box binding homeobox 1
- Aliases:
- BZP, ZEB, AREB6, NIL-2-A, Zfhep
- MANE:
- ENST00000424869.6
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Corneal abnormalities
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedCorneal dystrophy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownDDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownStructural eye disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
Fuchs endothelial corneal dystrophy
0.75posterior polymorphous corneal dystrophy 3
0.66posterior polymorphous corneal dystrophy
0.63corneal dystrophy, Fuchs endothelial, 6
0.57hereditary disease
0.47corneal dystrophy
0.47neurodegenerative disease
0.35glaucoma
0.35Visual loss
0.34ovarian dysfunction
0.32
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Zinc finger E-box-binding homeobox 1
Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). In the absence of TGFB1, acts as a repressor of COL1A2 transcription via binding to the E-box in the upstream enhancer region (By similarity)
Diseases associated with ZEB1
Curated MONDO disease pages that list ZEB1 among their top associated genes.