ZFPM2

Chr 8q23

zinc finger protein, FOG family member 2

Aliases:: PRDM19, FOG2, hFOG-2, ZNF89B
MANE:: ENST00000407775.7

OMIM: 603693 ↗NCBI: 23414 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ZFPM2 · Q8WW38

v62025-08-01

Predicted Aligned Error matrix for ZFPM2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

51.3/ 100

Low

1,151 residues

Confidence breakdown

Very high(≥ 90)6%
Confident(70–90)21%
Low(50–70)7%
Very low(< 50)66%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Differences in sex development
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Familial non syndromic congenital heart disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Paediatric disorders - additional genes
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

46,XY partial gonadal dysgenesis
0.72
diaphragmatic hernia 3
0.64
Tetralogy of Fallot
0.58
conotruncal heart malformations
0.56
atrial fibrillation
0.50
double outlet right ventricle
0.49
hypertensive disorder
0.46
breast carcinoma
0.45
neurodegenerative disease
0.45
venous thromboembolism
0.44

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Zinc finger protein ZFPM2

Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity)