ZFX

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• DDG2P

  X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)

• Fetal anomalies

  X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)

• Intellectual disability

  X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)

Disease associations (Open Targets)

• intellectual developmental disorder, X-linked, syndromic 37

  0.64

• neoplasm

  0.10

• hepatocellular carcinoma

  0.10

• non-small cell lung carcinoma

  0.10

• chronic myelogenous leukemia, BCR-ABL1 positive

  0.08

• colorectal carcinoma

  0.08

• renal cell carcinoma

  0.08

• breast cancer

  0.07

• breast carcinoma

  0.07

• cancer

  0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)