ZFYVE19

Chr 15q15.1

zinc finger FYVE-type containing 19

Aliases:: FLJ14840, ANCHR, MPFYVE
MANE:: ENST00000355341.8

OMIM: 619635 ↗NCBI: 84936 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

ZFYVE19 · Q96K21

v62025-08-01

Predicted Aligned Error matrix for ZFYVE19 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

69.3/ 100

Low

471 residues

Confidence breakdown

Very high(≥ 90)17%
Confident(70–90)37%
Low(50–70)22%
Very low(< 50)24%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Cholestasis
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

cholestasis, progressive familial intrahepatic, 9
0.75
neurodegenerative disease
0.28
metabolic syndrome
0.07
lower respiratory tract disorder
0.04
maturity-onset diabetes of the young type 10
0.04
MODY
0.04
permanent neonatal diabetes mellitus 1
0.04
thyroid gland carcinoma
0.03
hypertensive disorder
0.02
essential hypertension
0.02

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Abscission/NoCut checkpoint regulator

Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission