AlphaFold predicted structure
ZFYVE26 · Q68DK2
Mean pLDDT
65.3/ 100
Low
2,539 residues
Confidence breakdown
- Very high(≥ 90)0%
- Confident(70–90)57%
- Low(50–70)22%
- Very low(< 50)21%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
ZFYVE26
Chr 14q24.1zinc finger FYVE-type containing 26
- Aliases:
- KIAA0321
- MANE:
- ENST00000347230.9
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Adult onset hereditary spastic paraplegia
BIALLELIC, autosomal or pseudoautosomalAdult onset leukodystrophy
BIALLELIC, autosomal or pseudoautosomalChildhood onset hereditary spastic paraplegia
BIALLELIC, autosomal or pseudoautosomalDDG2P
BIALLELIC, autosomal or pseudoautosomalHereditary ataxia with onset in adulthood
BIALLELIC, autosomal or pseudoautosomalHereditary neuropathy
BIALLELIC, autosomal or pseudoautosomalHereditary neuropathy or pain disorder
BIALLELIC, autosomal or pseudoautosomalHereditary spastic paraplegia
BIALLELIC, autosomal or pseudoautosomal
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Disease associations (Open Targets)
hereditary spastic paraplegia 15
0.80Autosomal recessive spastic paraplegia type 15
0.71Spastic paraplegia
0.66hereditary spastic paraplegia
0.54hereditary disease
0.51Abnormal central motor function
0.36Tip-toe gait
0.36Intellectual disability
0.34Atypical behavior
0.34congenital myopathy
0.34
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Zinc finger FYVE domain-containing protein 26
Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair