ZMYM2

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• CAKUT

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• DDG2P

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Fetal anomalies

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Intellectual disability

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Early onset or syndromic epilepsy

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

• neurodevelopmental-craniofacial syndrome with variable renal and cardiac abnormalities

  0.77

• cancer

  0.60

• congenital anomaly of kidney and urinary tract

  0.56

• hereditary disease

  0.54

• acute lymphoblastic leukemia

  0.49

• leukemia

  0.47

• myelodysplastic syndrome

  0.46

• neurodevelopmental disorder

  0.46

• chronic myelogenous leukemia, BCR-ABL1 positive

  0.37

• syndromic complex neurodevelopmental disorder

  0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with ZMYM2

Curated MONDO disease pages that list ZMYM2 among their top associated genes.

• leukemiaRare