ZMYM3

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• DDG2P

  X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)

• Intellectual disability

  X-LINKED: hemizygous mutation in males, monoallelic mutations in females may cause disease (may be less severe, later onset than males)

Disease associations (Open Targets)

• intellectual developmental disorder, X-linked 112

  0.63

• prostate adenocarcinoma

  0.56

• neurodegenerative disease

  0.34

• medulloblastoma

  0.28

• B-cell chronic lymphocytic leukemia

  0.25

• lung adenocarcinoma

  0.22

• neurodevelopmental disorder

  0.22

• head and neck squamous cell carcinoma

  0.21

• lung carcinoma

  0.20

• small cell lung carcinoma

  0.20

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with ZMYM3

Curated MONDO disease pages that list ZMYM3 among their top associated genes.

• prostate adenocarcinomaRare